Orally administered targeted recombinant Beta-lactamase prevents ampicillin-induced selective pressure on the gut microbiota: a novel approach to reducing antimicrobial resistance.

A novel enzymic therapy, targeted recombinant ß-lactamase, in the prevention of antibiotic-induced adverse effects on gut microbiota

Analysis of Canine Small Intestinal and Fecal Microbiota Prevention of Ampicillin-induced Changes with Oral β-lactamase

Background: The intestinal microbiota affects many physiological and immunological functions of the body and is closely connected to the homeostasis and health status of an individual. Due to difficulties in obtaining samples from the intestine and studying complex microbial populations the knowledge of the composition, dynamics and metabolic potential of microbial populations in the upper gut ...

In vitro evaluation of the new oral cephalosporin cefatrizine: comparison with other cephalosporins.

Cefatrizine (BL-S640), a semisynthetic, orally administered cephalosporin, was found to have an in vitro spectrum of activity comparable to those of four other cephalosporins tested. It is as effective as cephalexin, the other orally administered cephalosporin evaluated, against most species, and it appears to be more effective than cephalexin against many Enterobacter, Haemophilus, and Proteus...

Iodometric detection of Haemophilus influenzae beta-lactamase: rapid presumptive test for ampicillin resistance.

Strains of Haemophilus influenzae type b sporadically isolated from clinical specimens are ampicillin resistant due to production of a beta-lactamase. This enzyme which inactivates ampicillin and penicillin G is not produced by ampicillin-susceptible strains. Various characteristics of beta-lactamase production and ampicillin resistance of three H. influenzae type b isolates were investigated. ...

Comparative trial of single-dose ciprofloxacin and ampicillin plus probenecid for treatment of gonococcal urethritis in men.

In a double-blind comparative trial, 100 men with uncomplicated gonorrhea caused by beta-lactamase-negative Neisseria gonorrhoeae were treated with a single 0.25-g dose of ciprofloxacin administered orally or with 3.5 g of ampicillin plus 1.0 g of probenecid administered orally. Urethral infection was eradicated in all 49 men treated with ciprofloxacin and in 47 (92%) of 51 men treated with amp...